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In this study, we found that systemic administration of a DRD1 antagonist can prevent anorexia and weight loss in the animals. Genetically and pharmacologically restoring the normal activity of the signal transmitted along the dopamine-serotonin brain circuit underlies anorexia in miceMidbrain dopamine (DA) and serotonin (5-HT) neurons regulate motivated behaviors, including feeding, but less is known about how these two populations of neurons in the brain. Deleting the DRD1 gene partially restored normal floxin antibiotic eating behaviors in animals. Clinical trials are already underway to test serine treatments in older adults experiencing cognitive decline.

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